Zero high dosage–response inverse relationship is actually seen between calcium supplements intake and you can threat of experience colorectal adenoma (Dining table dos)

Event colorectal adenoma

Compared with controls without polyps, incident adenoma cases were more likely to be male, smokers, physically inactive, have higher body mass index, and have higher intake of energy, but had lower intakes of calcium, magnesium and vitamin D (Table 1). However, intakes of calcium between 1200 mg and 1600 mg per day were associated with a significantly reduced risk of incident adenoma with an OR of 0.82 (95% confidence intervals (CI): 0.68–0.97) when compared with calcium intake between 600 and 1200 mg per day (referent group). When analyses were limited to incident advanced and/or synchronous adenomas, the inverse pattern of associations was found with a corresponding OR of 0.71 (95% CIs: 0.52–0.96) for calcium intake between 1200 and 1600 mg. When these analyses were stratified by the Ca:Mg ratio, the dose–response between calcium intake and advanced and/or synchronous adenoma were only observed in participants with a Ca:Mg ratio between 1.7 and 2.5 (P-trend, 0.05). The number of cases in the Ca:Mg ratio < 1.7 strata was too small to make meaningful statistical inference. There was no statistically significant communication between calcium and the Ca:Mg ratio (P-interaction: 0.11).

Metachronous (recurrent) adenoma

Weighed against people as opposed to metachronous adenoma, metachronous adenoma cases have been and more likely to be men and you may heavy, and also to possess high overall energy consumption but all the way down calcium supplements intake (Table step one). Metachronous adenoma instances was in fact less likely to feel white in order to possess family history from CRC.

I did not to see any mathematically significant connectivity anywhere between calcium supplements consumption and you will metachronous adenoma (Table 3). Connectivity was basically no different whenever analyses were broken down by the strata of California:Mg consumption proportion (Table 3), cutting-edge adenoma or parallel adenoma (Table step 3), place off adenoma (i.e., distal otherwise proximal, data not revealed) and you will standard adenoma properties (i.elizabeth., advanced/parallel adenoma) (Second Table 1).

CRC frequency

Compared with members exactly who don’t build CRC during the pursue-upwards, experience CRC cases during the standard was indeed more likely to become old, men, less inclined to large friends app enjoys attended college, less inclined to be aspirin profiles, expected to keeps history of CRC, and also highest bmi together with straight down consumption of calcium, magnesium and you will vitamin D (Desk 1). Shipments out of new member functions from the calcium consumption kinds try detail by detail inside the Additional Desk 2.

We found calcium intake was associated with a reduced risk of CRC (P-trend, 0.03) (Table 4). Closer examination of this association showed that the inverse trend between higher calcium categories and CRC was primarily present for distal CRC (P-trend, <0.01), but not for proximal CRC. In analysis stratified by the Ca:Mg intake ratio, we found the inverse trend between calcium intake and distal CRC was most pronounced in participants whose Ca:Mg ratio ranged from 1.7 to 2.5 (P-trend, 0.04). There was a statistically significant interaction between continuously modelled calcium intake and continuously modelled Ca:Mg ratio in relation to distal CRC (P-interaction, <0.01). When we further evaluated the relationship between calcium intake and distal CRC by randomisation status, the inverse trend across categories of calcium were similar in both groups, however, the association was statistically significant in the control arm (P-trend < 0.01), but not in the intervention arm (P-trend = 0.06) (Supplementary Table 3). Finally, when analyses were stratified by features of the baseline adenomas among individuals in the intervention arm, higher calcium intake trended towards reduced risk of CRC in individuals who had advanced/synchronous adenoma at baseline (P-trend = 0.04) (Supplementary Table 1)parable data were not available in the control arm.


As a result of the inconsistent facts regarding literature concerning your relationship anywhere between calcium supplements intake and you can colorectal carcinogenesis, we customized this study to address a couple wide questions, you to, if calcium consumption was protective up against colorectal carcinogenesis, at which stage(s) regarding carcinogenesis processes is it connection very true, which is the fresh new connection for the believed safeguards changed by the a beneficial balance involving the consumption percentages away from Ca and you will Mg. Regardless of if intake regarding calcium did not have a dose–impulse connection with experience adenoma of any proportions, we seen an enthusiastic inverse trend in terms of just experience state-of-the-art and you may/or parallel adenomas. I failed to select proof connection anywhere between calcium supplements intake and metachronous adenoma. I indexed a keen inverse trend between calcium supplements consumption and you can CRC and you will this development was somewhat determined by the connectivity which have distal CRC rather than simply which have proximal CRC. We up coming tested in case your inverse associations indexed more than was centered with the an enthusiastic optimally balanced Ca:Milligrams consumption ratio. Surprisingly, the fresh new inverse style noted for calcium consumption in terms of experience advanced adenoma and you will incident distal CRC had been extreme if the California:Milligrams consumption proportion is between 1.eight and you will 2.5.